The role of SH groups in the regulation of Gardos channels in glucose deficiency

Background. Disruption of the energy balance erythrocytes under conditions a decrease in glycolysis level can cause change ion permeability their membrane. The aim. To study Ca 2+ -dependent potassium membrane presence SH group modifiers glucose deficiency. Materials and methods. used precipitated obtained from blood 20 male Wistar rats. conductivity erythrocyte was determined using potentiometric method. A23187-and redox-induced hyperpolarization responses were evaluated. Results. Glucose deficiency medium, as well use inhibitor 2-deoxyglucose, led to an increase amplitude A23187-stimulated by opening Gardos channels. At same time, redox-dependent turned out be insensitive content medium inhibition. effects normal incubation multidirectional depended on method stimulation Conclusion. results indicate that metabolic disorders lead mechanisms control channels with participation groups proteins these or regulatory proteins.